

Influenza World brings you the latest news and updates in the flu field from around the world.
WASHINGTON (Reuters) - An antibody being developed by a Dutch drug company chokes off both seasonal flu and the H5N1 avian flu virus and might offer a way to develop better treatments and vaccines, researchers reported on Thursday.
Crucell NV's antibody, a naturally occurring immune system protein, grabs onto a hidden part of flu viruses, stopping them from infecting cells, they reported in the journal Science.
It is the second report in a week to find antibodies that can interfere with a range of strains of flu -- one of the hardest viruses to fight because it mutates so much.
"This is very exciting because it marks the first step toward the Holy Grail of influenza vaccinology -- the development of a durable and cross-protective universal influenza virus vaccine," Ian Wilson, a researcher at he Scripps Research Institute in La Jolla, California, who helped lead the research, said in a statement.
"Such a flu vaccine could be given to a person just once and act as a universal protectant for most subtypes of influenza, even against pandemic viruses."
On Sunday, another research team said they had found a batch of antibodies that do something similar.
Flu vaccines and drugs focus on proteins found on the surface of the flu virus called hemagglutinin and neuraminidase, which give influenza A viruses their names, as in H5N1 or H1N1.
Hemagglutinin is a lollipop-shaped structure with a big, round head. This head is so large that it attracts most of the immune system antibodies - which then slip off when it mutates.
Because of the mutations, vaccines have to be reformulated every year and the viruses can develop resistance to antiviral drugs.
The antibodies found by Wilson's group and the U.S. team earlier this week attach to the "stick" of the hemagglutinin lollipop. This mutates less than the head, and so provides less of a moving target.
In both studies, the antibody suppressed a range of flu viruses, including H5N1 avian flu and the currently circulating H1N1 seasonal flu virus, although they did not work well against another seasonal flu virus called H3N2.
Wilson's team and Crucell Holland found their antibody, called CR6261, in the blood of people who had been vaccinated with the ordinary seasonal flu vaccine.
Similar antibodies have now also been found in other people, but it is not clear how well they protect people from flu or whether some people's bodies use them more efficiently than others.
Both groups said their antibodies provide a way to treat people infected with flu, as well as a route to designing better drugs and vaccines.
- "I would describe flu as something that makes you feel very, very ill. You get a headache, aching bones, and are generally fed up"
- "When I get flu symptoms I feel like a train has run over me"
- "I felt very sick and, during the first week, I had high temperature. Flu was very different to a cold. I went back to work after two and a half weeks. Then I suffered a setback for another week"
- "I run a guesthouse; flu would be a real pest for me. I couldn’t cook, I shouldn’t cook, and I wouldn’t cook, so I would need to get a lot of extra help in. It would cost me a lot more money. So flu’s a real problem, a right downturn"
- "I work on my own and when I can’t work, I have to try not to infect my little children, so they avoid getting the flu as well"
- "I feel a little numb, like I’m in another dimension. Because in general I have sore throat, headache, I feel all clogged-up. Usually a sensation like I’m floating in the air"
- "Shivers, sweats, makes you ache. Last time I had flu I was off for two weeks"
- "I think that I would probably be concerned that I would pass flu onto my children, who might not be able to deal with it as well as I would"
- "Flu makes you feel like you’ve been hit over the head with a baseball bat. You don’t feel like you can get yourself out of bed as all your energy is drawn from you"
- "I was incapable of working. It just wasn’t possible at all… and my flu dragged on for more than a week"
- "I have no strength. It annoys me because I can do nothing, it seems like I’m wasting my time"
- "Flu’s like being hit by a truck because you feel completely gone. There is no energy left in your body. You are suffering from high temperature. You’re sweating a lot and you feel really unwell"
- "First of all infinite tiredness, then I feel like sleeping and don’t want to eat"
- "I felt really miserable because my muscles and my bones were aching. Well, I can hardly describe it, I just felt really awful, absolutely miserable"
- "It’s like there’s something huge treading on your head, like a deafening noise that destroys the eardrums"
- "The fever was constantly rising – I immediately measured my temperature as soon as I got home. It was 41°C and it kept rising and I was wondering what’s going on. I was really scared! Everything was hurting and it all happened so fast. Flu came out of the blue"
- "I always feel like my limbs have iron weights tied to them and I’m going to fall over any minute, a really stuffy runny nose and feel antisocial"
- "I was totally dependent on others! I was incapable of doing anything at all"
- "The real flu knocks you for six – you just don’t want to move or do anything. It’s not very nice"
- "Not being able to go to work. Not being able to do the things I have to do at home and the commitments that I have day by day"